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These results provide new insights into the molecular basis of ligand specificity in class B GPCRs and may facilitate the development of more specific therapeutics.

GLP-1 receptor agonist 7 generates cAMP under the mediation of GLP-1R with an EC50 of 0.2 nM

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Phentermine should not be used concurrently with tirzepatide for weight management due to lack of safety data on this combination and potential overlapping s...