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Diagnosis typically requires clinical evaluation, laboratory testing (serum lipase is the preferred diagnostic enzyme, typically elevated to three times the upper limit of normal), and imaging studies such as CT scan or abdominal ultrasound

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A, Glucose tolerance ability after HFD induction

Still, we can speculate what might be happening based on our understanding of how the body responds to weight loss, including altered metabolism, reduced blood flow to extremities, decreased food-induced heat production, and loss of insulating body fat