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Drug interactions are most clinically important with insulin and sulfonylureas (hypoglycaemia risk), DPP-4 inhibitors (dont combine), and (for Mounjaro only) oral contraceptives and oral HRT

This competitive architecture creates distinct strategic layers: duopoly incumbents maximizing anti-obesity medication penetration

That practical distinction has significant implications for real-world adherence and patient access

However, this marketing is misleading for several reasons

The gut: More than digestion GLP-1 has a substantial impact on the gastrointestinal (GI) system

MASH can involve liver inflammation, liver cell injury, and fibrosis, which means scarring of the liver