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Effects of empagliflozin on first and recurrent clinical events in patients with type 2 diabetes and atherosclerotic cardiovascular disease: a secondary analysis of the EMPA-REG OUTCOME trial

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That fiscal backdrop helps explain why most public plans have so far limited GLP1 coverage to diabetes, even as evidence for weightloss and cardiometabolic benefits in people with obesity has grown

This establishes a direct neuroendocrine bridge between oral GLP-1 signaling and the central components of the GBA, where it converges with intestinal GLP-1-mediated pathways to regulate appetite and reward processing (58, 61, 168, 169)