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Common side effects include nausea, vomiting, diarrhea, constipation, abdominal discomfort, headache, fatigue, and injectionsite reactions
Appetite Changes and Fast Weight Loss Because retatrutide works on hormones that affect hunger, you may feel less interested in food

Two randomized control clinical trials reported conflicting effects on bone mineral content (BMC) and bone mineral density (BMD): one trial demonstrated preservation of BMC with GLP-1 use, while the other found no significant difference in BMC or BMD between treatment and control groups
Because it addresses the production of acid, it is often taken once a day to provide long-term relief rather than immediate, short-term fixes
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