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Week 1-4: 1mg weekly Week 5-8: 2mg weekly Week 9-12: 4mg weekly Week 13-16: 6mg weekly Week 17-20: 8mg weekly Week 21+: 12mg weekly (if tolerated) The Phase 3 TRIUMPH-4 trial used a slightly modified approach

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Recent 2.8 cryo-electron microscopy (cryo-EM) reconstructions reveal that agonist engagement drives an outward swing of transmembrane helix 6 and creates an open intracellular cavity that pre-associates with G s , clarifying how the receptor achieves rapid activation and sustained cyclic adenosine monophosphate (cAMP) output [10]

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