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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Mallinson CN, Bloom SR, Warin AP, Salmon PR, Cox B

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Recent data highlight average weight loss of over 24%, with significant reductions in total and visceral fat masssurpassing current GLP-1 options like Mounjaro and Wegovy

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In particular, pretreatment with the GHSR1a inverse agonist SP-analog results in cross-sensitization to the 5-HT 2C response in cells coexpressing GHSR1a and 5-HT 2C (Schellekens et al., 2013)