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Description
Bitter Orange Extract Bitter orange extract is found in some citrus fruits and contains synephrine, a stimulant with effects similar to ephedrine (a dangerous ingredient banned by the FDA for use in diet and sports supplements because it showed to have serious health risks like heart attack and stroke, resulting in deaths), according to a 2022 review of the safety and efficacy of bitter orange extract in Nutrients

mostly mild-moderate and transient Vomiting: 20% vs

doi: 10.1002/advs.202206798 127 WangJShanmugamAMarkandSZorrillaEGanapathyVSmithSB
10.1152/ajpendo.00565.2005 113

Additionally, it slows down gastric emptying, prolonging the feeling of fullness and reducing the urge to overeat

This pattern suggests individual response variation rather than tolerance development
