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Its important to understand how it fits with other treatments

5 tips for staying hydrated on a GLP-1 Staying hydrated on a GLP-1 is important to prevent dehydration, and may even support healthy weight loss

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Comparison with the binding modes of other dual and triple agonists highlight that the N-terminal and C-terminal regions of the peptide confer receptor selectivity, whereas the middle region offers opportunities for sequence optimization to refine receptor engagement, thereby presenting a useful template for designing better unimolecular therapeutics

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Lancet 397(10278):971984 Garvey WT, Frias JP, Jastreboff AM et al (2023) Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial