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The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats

[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Costabile A., Kolida S., Klinder A., Gietl E., Buerlein M., Frohberg C., Landschtze V., Gibson G.R

applied a high dimensional approach to analyze associations between GLP-1 treatment and health outcomes in over 1.9 million persons over an average of 3.68 years based on data from the US Department of Veterans Affairs and found, in addition to gastrointestinal and other common symptoms, a significant increase in hypotension, joint pain, kidney stones, and nephrolithiasis [190]

Importantly, phosphorylation of AKT also occurs downstream of GPCR signaling either directly through PI3K, or indirectly by upregulation of reactive oxygen species, resulting in tissue-specific AKT activation or inhibition (59-61)

modulates immune aging and protects pancreatic islet cells in autoimmune diabetes models [5] [10]

However, it remains unclear whether baseline potassium intake levels alter the magnitude of blood pressure reduction from sodium restriction (55)