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Genetic variants in your GLP1R receptor and other peptide-pathway genes influence how effectively semaglutide works in your body

That combination is exactly why deliberate water intake matters more on semaglutide or tirzepatide than it does off them

Retatrutide is an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors currently undergoing clinical trials

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[8] [9] However, this does not mean the question is entirely without clinical relevance