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For female patients, contraception and the safety of pregnancy should be addressed starting in the first visit

Similarly, the Medical Research Council (MRC) ALL 97/99 study randomized 1603 children with standard- and high-risk ALL and those who received dexamethasone (6.5 mg/m 2 /day) rather than prednisolone (40 mg/m 2 /day) during the induction, consolidation, and continuation phases had half the risk of isolated CNS relapse (2.5% vs

January 17, 2026

Gradual titration helps the body adapt to changes in appetite and digestion

Among 14 studies reporting lifestyle or placebo comparator data, median weight loss was only ~2.4%, but 50% of those interventions still exceeded the muscle-loss benchmark

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