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In June 2025, the TGA issued a medicines safety update requiring consideration be given to the risk of delayed gastric emptying and aspiration when providing anaesthesia or deep sedation for patients using these drugs

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While the physiological relevance of irisin in humans is under investigation, growing preclinical evidence suggests its role in lipid metabolism, browning of white adipose tissue, and glucose uptake

These symptoms may complicate the diagnosis and management of perioperative conditions that share similar clinical presentations

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NCT05520775: Semaglutide for Alcohol Use Disorder Status: Underway This is an early-Phase II human trial using a randomized, placebo-controlled, dose-ranging design to investigate the effects of semaglutide, a GLP-1 receptor agonist, on alcohol-related outcomes in adults with alcohol use disorder