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The combination therapy of GLP-1 receptor agonists and metformin demonstrates superior safety over monotherapy, while revealing novel adverse events and demographic-specific risk patterns, thereby offering reliable evidence to inform clinical practice.

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Both human and animal studies reported inconsistent BP response to acute administration but showed hypotensive effect of chronic administration of GLP-1/ GLP-1 RAs

This Phase 3 medical study run by Novo Nordisk A/S needs participants to evaluate whether CagriSema will have tolerable side effects & efficacy for patients with Hyperalimentation and Obesity and Obesity