glp 1 gip gcg Biology of Incretins: GLP-1 and Glucagon, GLP-1 and Thermogenesis

Some GLP-1 agonists, like semaglutide and high-dose liraglutide, are also FDA-approved for treating obesity

Key Toxicities to Watch as a clinical pharmacist: Renal: nephrotoxicity, rising creatinine Neuro: tremors,confusion, seizures Metabolic: hypertension, QT prolongation, hyperglycemia Electrolytes: K, Mg Heres how we intervene before toxicity takes over: Slash Tacrolimus doses by ~70% when starting Posaconazole TDM every 23 days (dont wait for trouble) Monitor renal function, BP, electrolytes, glucose closely Anticipate the reverse interaction when Posaconazole is stopped tacrolimus levels crash without timely adjustment Key Insight: Pharmacists arent just dose adjusters. We are the safety net that spots silent drugdrug collisions before they harm patients

Enyhthetik a szkrekedst a blmikrobiom sszettelnek befolysolsval

Exercise addresses multiple causes of weight gain simultaneously

More GLP-1 was needed to have the same biological effect, meaning they were resistant to GLP-1. Seeking confirmation The results were so surprising, Gloyns team spent the next several years confirming them

Liraglutide reduces cns activation in response to visual food cues only after short-term treatment in patients with type 2 diabetes