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Furthermore, several of these therapies have only a modest glucose-lowering effect in people with reduced glomerular filtration [14]

GLP-1 RAs exerted neuroprotective effects by inhibiting glutamate accumulation to prevent excitotoxicity and neural apoptosis [39], which possibly explains the protective effects of the GLP1R gene on background DR and severe nonproliferative DR, but not proliferative DR

Journal of Endocrine Society

Celebrity Gabriel Iglesias is a notable example of this yo-yo effect, and data suggest that half of patients stop taking the medication within one year and 70 percent within two years

Symptom journal: Brief daily notes about pain, diet limits, or missed workdays can strengthen credibility when paired with provider notes

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