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Batch variability: Toxicity parameters may vary across synthesized batches due to differences in purity, residual solvents, or counterion composition

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doi: 10.1016/s0196-9781(97)00016-8 91 FrieboesRMMurckHMaierPSchierTHolsboerFSteigerA

This suggests that the triple-agonist mechanism achieves equivalent results at lower relative doses, which has implications for side effect burden and cost