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What the research says about supplements to take with GLP-1 drugs, plus why 'natural GLP-1' pills are mostly marketing.

Hills research does suggest that, while the API is a minor cost component compared to the pen in an injectable formulation, the need to dose daily for a higher API load in a pill makes orals pricier to manufacture than injectables, further raising the competitive advantage of manufacturing small molecule alternatives, such as Lillys orforglipron

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Unlike the well-known roles of GLP-1 and #PYY, the role of INSL5 is poorly understood, but this new research suggests it promotes colonic motility and in fact may be behind the cases of severe diarrhea (bile acid malabsorption in #IBS)

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