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Most side effects are gastrointestinal and tend to diminish as the dose is gradually increased

Alcohol is a diuretic, meaning it dehydrates you further

A meaningful percentage of people starting semaglutide or tirzepatide discontinue due to side effects

10.1016/j.cmet.2017.04.013 27 GreinerT

Jardiance is a member of a class of medications known as sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors), which control day-to-day blood sugar by reducing the reabsorption of filtered glucose in the kidneys, resulting in increased urinary excretion of glucose and lowered blood sugar concentrations

8 GLP-1 RAs achieve this by downregulating proinflammatory cytokines and, in particular, by suppressing nuclear factor (NF)-B signalling