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Tirzepatide has the potential to prevent atherosclerosis risk in T2DM patients without pre-existing lesions

By 2030, it is expected that this number could grow to more than 1 billion people, with over 120 million of those in the U.S

Annu Rev Pharmacol Toxicol

Overall, these results indicate GLP-1RAs can influence a number of proteinopathies across disease models, although more understanding is required to determine when in the course of disease proteostasis can be modulated to bring about reduced neuronal loss and clinical benefit

Drug choice, dose, and penetration : Differences among GLP-1 RAs in ability to affect the brain (bloodbrain barrier penetration, receptor binding, half-life, dosing) may influence outcomes

Zhang Q, Li Q, Liu S, et al