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The following side effects have been reported in subjects taking 3mg liraglutide for weight loss [24]: Nausea (39.3%) Diarrhea (20.9%) Constipation (19.4%) Vomiting (15.7%) Headache (up to 13.6%) Increases in mean resting heart rate (over 10% ) Less common side effects that occur in less than 10% of patients are: Dyspepsia Abdominal pain Gastroesophageal reflux disease Eructation Flatulence Dry mouth Elevated pancreatic enzymes Constipation Gastritis Abdominal discomfort Hypoglycemia Dizziness Hypotension Injection site reactions (pain, bleeding, redness, swelling, or itching) Rare but serious side effects include pancreatitis, gallbladder disease, cholestasis, and allergic reactions

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Current research and clinical experiences suggest potential benefits, but also underscore the need for ongoing scrutiny and patient-specific adjustments

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The primary concerns are cardiovascular strain (increased heart rate/blood pressure) and severe dehydration/malnutrition due to the combined effect of both drugs on your central nervous system and gut.