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doi: 10.1007/s40272-020-00410-6 406 Tan-LimCSCEsteban-IpacNARRectoMSTCastorMARCasis-HaoRJNanoALM

The safety profile of orforglipron in Phase 3 trials has been consistent with the GLP-1 receptor agonist class

Side Effects and Safety: Whats Similar and What Might Differ Weight loss medications can have major benefits, but they can come with side effects, too

The complete caffeine-GLP-1 interaction guide timing, quantity, acid reflux, and how coffee helps constipation

10.1038/s41598-017-08271-9 [DOI] [PMC free article] [PubMed] [Google Scholar] 99.Bugliani M, Syed F, Paula FMM, Omar BA, Suleiman M, Mossuto S, et al

Around the same time, I think you remember that all of pharma was interested in obesity in the early 90s, everyone wanted to do diabetes as well as obesity, but they were separate teams and they all wanted to do small molecules, but it just happens to be so that the best idea we could find at that time was actually GLP-1, because we actually had clinical data relatively early that GLP-1 was a really good candidate as a treatment for diabetes because of the glucose sensitivity of the actions
