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FDA-approved drugs undergo rigorous testing and must be proven to work as intended in clinical trials

When used as monotherapy or with medications that do not independently cause hypoglycemia, tirzepatide has a low intrinsic risk of causing clinically significant hypoglycemia

Three randomized clinical trials, namely SURPASS-3, SURPASS-4, and SURPASS-AP-Combo, with 4339 patients were included

This may blunt long-term sustainability of weight loss, as discontinuation of the drug has been associated with weight regain unless lifestyle strategies are continued [19]

Regularly monitor your blood sugar (especially if you are diabetic) to ensure safety

The baseline utility value for obesity was set at 0.80 quality-adjusted life-years (QALYs)