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In the ATTAIN-1 phase 3 clinical trial, participants on the highest dose who remained on treatment lost an average of about 12.4 percent of their body weight approximately 27.3 pounds over 72 weeks, compared to less than 1 percent for those on placebo

Duloxetine treatment and glycemic controls in patients with diagnoses other than diabetic peripheral neuropathic pain: a meta-analysis

For general injection guidance , see the linked protocol

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The goal is to maximize the weight loss while being able to get patients off the drug in the future in a way that they dont feel like theyre going to regain the weight. Weight loss using GLP-1 medication varies by individual, but data suggest it is from 10% to 20% of total body weight over one year