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Cost was also a notable barrier (12.8% of patients discontinued due to affordability)
Slowing kidney decline in the SURPASS-CVOT trial In patients with high or very high risk chronic kidney disease enrolled in SURPASS-CVOT, tirzepatide dramatically slowed the rate of kidney function decline compared to dulaglutide

European Heart Journal

GLP-1 receptor agonists like semaglutide are engineered analogs that resist degradation, extending their half-life to approximately one week

b Indications that may warrant additional assessment and/or laboratory testing prior to therapy: Prior history of a very low-calorie diet, bariatric surgery, celiac disease, other inflammatory conditions predisposing to nutrient deficiency

Fiber supports digestion without overwhelming it Fiber is your best friend on GLP-1 therapy, but only in the right amounts
