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Background Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) reduce the risk of major adverse cardiovascular events (MACE) in patients with type 2 diabetes mellitus (T2DM)

Methods This is a cohort study combining several population-wide databases and covering a Spanish population of five million inhabitants, including all adults with obesity who initiated treatment with either GLP-1RA or SGLT-2i for type 2 diabetes from 2015 to 2021

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For example, semaglutide and empagliflozin showed no significant difference in 3-point MACE (HR 1.05

Limitations The major limitations of the studies that are included in this systematic review are the enrollment of healthy subjects and insufficient data in conditions that might affect pharmacokinetics (e.g., kidney dysfunction)

CMS GLP-1 Bridge Program: Medicare Part D coverage for weight-loss GLP-1 drugs starting July 1, 2026, including eligibility, covered medications, prior authorization, and copay rules.