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New Data: Phase 3 TRIUMPH-4 Results (Retatrutide) Eli Lilly just released topline results from the Phase 3 TRIUMPH-4 trial, evaluating the triple hormone receptor agonist retatrutide in patients with obesity and knee osteoarthritis (OA)

The cohort comprised patients over 20 years old who were newly treated with glucose-lowering drugs between 1 January 2013 and 31 December 2021, and followed until 30 September 2022

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The combination therapy of GLP-1 receptor agonists and metformin demonstrates superior safety over monotherapy, while revealing novel adverse events and demographic-specific risk patterns, thereby offering reliable evidence to inform clinical practice.

Clinicians should maintain heightened awareness for aspiration risk in perioperative settings