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including PIONEER 15, 7 and 8, a total of 5657 patients were included in the analysis
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For test compounds that were insoluble in water (Y1-R antagonists) stocks were made up at 1000 times the assay concentration in DMSO, so that final concentration of DMSO in the assay was 0.1%

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However, the fatigue may persist into the following morning for some people
