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Anhedonia and Depression on GLP-1s Because GLP-1s dampen dopamine release, there is a risk of dopamine blunting. This happens when the body doesnt release enough dopamine and causes emotional flatness

These mechanisms complement rather than compete, which is why many providers recommend continuing metformin when initiating semaglutide, tirzepatide, or oral alternatives like those offered through PlexusDx

Telehealth platforms make this easier: after a short online intake form and medical review, most providers can issue a prescription within 2472 hours without an in-person office visit

"Prescriptions quadrupled between 2020 and 2022 to roughly 9 million , demonstrating unprecedented demand growth." HealthJoy Research How did stronger formulations change medical outcomes

Respirol (2014) 19(5):62535

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