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Researchers investigated cell proliferation, levels of phosphoinositide 3-kinase/AKT serine/threonine kinase (Akt) and mitogen-activated protein kinase/extracellular signal-regulated kinase (Erk) signaling pathway members, and metabolic activity of cell lines exposed to GLP-1 RAs, concluding that GLP-1 RAs may not influence cell proliferation or energy metabolism in PTC cells

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Reynolds AN, Akerman AP, Mann J

A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors

More GLP-1 was needed to achieve the same biological effect, indicating the participants were GLP-1-resistant