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When the shape changes, the medication may no longer fit into the receptors in your body correctly

114 GLP-1 also upregulates the activities of c-Src kinase, 115 phosphatidylinositol 3-kinase (PI-3-kinase), 116 protein kinase B (PKB), 117 protein kinase c-zeta (PKC-), 118 and extracellular signal-regulated protein kinases (ERK1/2)

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Side Effects and Tolerability: All three drugs have similar side effect profiles , since they all work on the incretin system