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Some patients experience joint pain within weeks

CMS rules now require certain impacted payers to respond within 72 hours for expedited requests and 7 calendar days for standard requests, though real-world timelines vary by plan type, drug, and documentation completeness

They produce weight loss (versus weight gain with insulin), have lower hypoglycemia risk, and have proven cardiovascular benefits that insulin lacks

Secondary searches were performed using Google Scholar and regulatory sources, e.g., US Food and Drug Administration (FDA) labels and European Medicines Agency (EMA) reports, to capture gray literature and pharmacovigilance data

Rapid weight loss may leave the skin with less elasticity and support, especially if the skin was stretched for many years