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demonstrated that liraglutide reduced pathology-specific tau phosphorylation and improved motor function in a transgenic hTauP301L mouse model of tauopathy [57]

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An engineered G s construct (mini-G s ) was used for expression and purification of the compound 2LY3502970GLP-1R complex, which was designed based on that used in the determination of A2AR-mini-G s crystal structure 48