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Description
Patients who lost less than 20 pounds on GLP-1 medications and were subsequently prescribed phentermine experienced greater weight loss while on phentermine in the year following GLP-1 treatment than patients who lost at least 20 pounds on the GLP-1 medication.
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These effects were observed with central, but not peripheral, administration of the agonist and antagonist, suggesting receptor expression on the luminal, CSF-facing side of the choroid plexus, which aligned with GLP-1R-mediated modulation of luminally-expressed transporters in excised choroid plexus
Accessed October 30, 2025
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Lyophilized research material for laboratory use only
