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Future research endeavors should prioritize identifying the variables responsible for heterogeneity in meta-regression analyses, including factors such as gender, drug dosage, and study duration, which can impact changes in HbA1c and weight

doi: 10.1016/S0140-6736(22)02076-1 73 Rivera-MartnezWMeja-CardonaASalazar-SolarteAAristizabal-ColoradoDGarces-VillabonLPinillos-SeniorOet al

Moreover, there is a scarcity of highlevel evidence regarding its pathophysiology, prevalence, and response to treatment, highlighting the need for studies to improve diagnostic and therapeutic strategies

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