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Tirzepatide Dual Agonist (GLP-1 + GIP) Extensive Phase 3 data (SURMOUNT) Primary focus: Insulin sensitivity Retatrutide Triple Agonist (GLP-1 + GIP + Glucagon) Emerging Phase 2/3 data (TRIUMPH) Primary focus: Energy expenditure + Lipids Biochemical Architecture: Dual vs

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Data on intermittent GLP-1 receptor agonist use are limited