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In addition, cardiometabolic parameters were improved, including blood pressure, triglyceride levels, and high-sensitivity C-reactive protein

Extensive research supports the long-term use of these medications, highlighting their potential benefits for various health conditions, including thyroid issues and autoimmune diseases

4 When you lose weight quickly, your body also loses water and essential minerals

Until targeted gene-specific therapies become widely available and effective for all MC4R variants, GLP-1 RAs represent a crucial therapeutic tool, offering a path toward significant clinical benefit for patients grappling with this challenging form of monogenic obesity

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"There needs to be more gold-standard, randomized, controlled clinical trials to understand the true potential of berberine," says Dana Ellis Hunnes, PhD, MPH, RD, a UCLA Health senior clinical dietitian