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Peker, Y

Weight loss may lag behind changes in appetite due to normal metabolic adaptation, so early reductions in hunger do not always translate into weight loss

Discontinuation rates due to GI intolerance were 3-7% across doses, comparable to tirzepatide

Doctors discuss possible risks before treatment begins

Tirzepatide works on both GLP-1 and GIP receptors, which may provide additional metabolic benefits and stronger appetite regulation for some individuals
