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Key features of this combination include: Two complementary mechanisms of glucose reduction Significant HbA1c reduction potential Additional benefits beyond glycaemic control Reduced risk of hypoglycaemia compared to insulin-based regimens (though caution is needed if combined with insulin or sulphonylureas, which may require dose reduction) How GLP-1 Receptor Agonists and SGLT2 Inhibitors Work Together Understanding the distinct pharmacological mechanisms of these two drug classes helps explain why their combination can be effective

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10.1016/j.ecl.2020.10.002 Endocrinol Metab Clin North Am