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Combines appetite control (GLP-1/GIP) with increased energy expenditure (Glucagon)

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NICE has backed use of the Wegovy (semaglutide) for people with a body mass index (BMI) of 35 kg/m2 or more and at least one weight-related ailment such as high blood pressure, high cholesterol or diabetes as part of a weight management programme involving exercise and a reduce-calorie diet.

Significant weight loss: In clinical trials, retatrutide has shown substantial weight loss compared to placebo

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