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In the beginning, when you lose weight, your body significantly decreases energy intake and only gets energy from other sources, such as glycogen

Research shows that GLP-1 receptor agonists maintain therapeutic levels when dosed at regular weekly intervals, and missing a dose by 12 days typically does not significantly reduce effectiveness
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In type-2 diabetic models (genetically-inherited or diet-induced obesity), exenatide significantly enhances bone strength by increasing trabecular bone mass, bone formation and trabecular microarchitecture
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Launched in India in June 2025, Wegovy demonstrated strong clinical efficacy, with about one in three patients losing more than 20% of their body weight during trials