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Aim for at least 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity exercise per week

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But the WHO guideline matters because it influences global health policy, insurance coverage decisions in some countries, and the general medical consensus about when these drugs are appropriate

Now, it takes the stage in neurology, with a potential disease-modifying role that raises a broader question: have we underestimated the interface between metabolism and the brain

T.WeiL.et al (2016)

Absence of LepR in astrocytes weakens pSTAT3 signaling and increases TCPTP level, leading to altered glial morphology, reduced astrocytic coverage of melanocortin cells, and augmented synaptic inputs onto hypothalamic neurons [195, 196]