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Most experience the most intense tiredness during the initial 4 to 8 weeks, but it tends to recede with time, cleaner eating, and proper hydration

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The journey of GLP-1RAs began with the approval of exenatide in 2005, the first medication of its kind

11 Figure 2: The likelihood of patients being diagnosed with depression after a GLP-1 prescription compared to those on a non-GLP-1 medication 11 Initial studies on the risk of suicide in individuals taking GLP-1s indicate that these drugs may increase suicidal thoughts and ideation