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P = .028

As the half-life of retatrutide is 6 days, once weekly administration was sufficient with as expected gastrointestinal disturbance being the most common side effect and occurring in 63% of those on retatrutide, 60% on dulaglutide, and 54% of the placebo cohort [63]

The potential antidepressant effect of antidiabetic agents: new insights from a pharmacovigilance study based on data from the reporting system databases FAERS and VigiBase