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Practical challenges of sublingual tirzepatide Contact time
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In brief, in SURMOUNT-1, participants were randomized 1:1:1:1 to once-weekly, subcutaneous tirzepatide (5, 10, or 15 mg) or placebo for 72 weeks, followed by a 4-week safety follow-up period without treatment
In the SURMOUNT-1 clinical trial, patients without diabetes lost an average of 15-21% of baseline body weight over 72 weeks, depending on dosage, with somewhat lower averages observed in patients with type 2 diabetes in SURMOUNT-2
Average weight loss at week 12 was 8.7%, increasing to 17.3% by week 24, and reaching 24.2% by week 48
