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GLP-2, marketed under the brand name Mounjaro, represents a groundbreaking advancement in the management of Type 2 diabetes and obesity

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Most patients notice early appetite changes within days of starting semaglutide, with measurable weight loss typically appearing by week 3 to 4 of treatment

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These findings demonstrate that both basal and agonist-induced GLP-1R phosphorylation are critical for receptor signalling in -cells, revealing a previously unappreciated role for basal phosphorylation in shaping receptor behaviour and establishing a positive link between GLP-1R phosphorylation and -cell signalling competence