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Description
Interestingly, GLP-1(2836) amide, a metabolite that does not bind to GLP-1R, was found to protect against cardiac injury in mice after LAD artery ligation by a mechanism involving mitochondrial trifunctional protein- (MTP) and intracellular soluble adenylyl cyclase (sAC) in cardiac smooth muscle and endothelial cells, but not cardiomyocytes (24)
Is GLP-1 safe to use during menopause
Tirzepatide activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors the dual-receptor mechanism that produced the SURMOUNT trial results
doi: 10.1186/s13395-015-0060-8, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 134
These factors highlight the importance of ongoing professional guidance
Others continue treatment for 12+ months for greater weight loss or to ensure maintenance
