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Oral GLP-1 weight loss medication Orfoglipron (Eli Lilly) is nearing an FDA decision with available expect mid-2026 Clinical trials show meaningful results: 12-16% 1,2 average weight loss, which is slightly less than injectables Side effects are similar: mostly gastrointestinal, such as nausea or diarrhea, typically improving over 23 months

Additionally, people with medical conditions or complex health needs should think twice

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Or if youre gradually adding five or 10 pounds to a lift over time, thats a meaningful indicator that your muscles are adapting

Data from small studies suggest preconception GLP-1 use may help improve pregnancy odds in this patient population

GLP-1 medications avoid this problem because they work on peripheral hormone systems that do not develop tolerance in the same way