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[DOI] [PubMed] [Google Scholar] 143.Wadden TA, Chao AM, Machineni S, Kushner R, Ard J, et al

Nausea rates in retatrutide trials reached approximately 45% at the maximum dose, compared to roughly 31% for tirzepatide

The answer, though, is almost certainly simpler than you think

They compared individuals using GLP-1RAs with those on more traditional antihyperglycemics, such as sulfonylureas, DPP-4 inhibitors, and SGLT2 inhibitors

Management of Hyperglycemia in Type 2 Diabetes, A consensus report by the american diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Regardless of if youre someone looking to try these alternatives or just curious about the developing GLP-1 market in general, I hope this article gave you a little insight into the future of weight loss drugs and supplements.
