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The additional GIP receptor activity in tirzepatide does not appear to add thyroid risk, as GIP receptors are not significantly expressed on human thyroid C-cells
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Its greatest clinical value often lies in two important yet under-recognized applications: First-line therapy for cholestatic pruritus, where interruption of enterohepatic circulation reduces circulating bile acids and improves quality of life
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Fortunately, this fatigue is often temporary and manageable with the right strategies
